Bull. Chem. Pharma Res., 2017, 1(2), 45–48.

Abstract: Chitosan, a polysaccharide has many industrial applications and its miscibility studies with highly useful synthetic PVA  has become a subject of current research interest. Hence the Viscosity, Ultrasonic velocity, and Refractive Index measurements were carried out for Chitosan, PVA, Chitosan/PVA blend of (50/50) composition in 2% aqueous Acetic acid solution at 30°C, 40°C and 50°C. The interactions in binary polymer systems were analyzed from the viscosity data by computing interaction parameters µ and α. These values revealed that the Chitosan is compatible with PVA. This was further confirmed by Ultrasonic velocity and Refractive index results. The miscibility behavior of Chitosan/PVA blend was also discussed by varying the temperature.

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Bull. Chem. Pharma Res., 2017, 1(2), 40–44.

Abstract: A rapid, accurate, and precise RP-HPLC method has been developed for simultaneous separation and quantification of olmesartanmedoxomil and indapamide in tablet dosage forms. The separation of both the drugs was achieved on an Enable C₁₈ column (250 x 4.5 mm;5µm) using a mixture of methanol and acetonitrile (95:5v/v) as the mobile phase. The flow rate was 0.8 mL/min and detection of the drugs was done at 245 nm. The retention times obtained for olmesartan and indapamide were 2.1 and 3.5 min respectively. The linearity range found for both olmesartan and indapamide was 5-25 µg/mL. The average percentage recoveries obtained by the proposed method for olmesartanmedoxomil and indapamide were 99.45% and 99.42% respectively. The results of the analysis were validated as per ICH guidelines. The proposed method can also be successfully employed for simultaneous determination of both the drugs in tablet dosage forms.

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